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KMID : 1137820140350040095
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의공학회지
2014 Volume.35 No. 4 p.95 ~ p.98
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Evaluation of Baroreflex Effectiveness in Normal Subject and Obstructive Sleep Apnea Patient during Sleep using Granger Causality Analysis
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Jung Da-Woon
Kim Sang-Kyong
Kim Ko-Keun
Lee Yu-Jin
Jeong Do-Un
Park Kwang-Suk
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Abstract
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The baroreflex is one kind of homeostatic mechanisms to regulate acute blood pressure (BP) changes by controlling heartbeat interval (HBI). To quantify the effect of baroreflex, we suggested a new approach of analyzing Granger causality between systolic BP (SBP) and HBI. The index defined as baroreflex effectiveness (BRE) was generated by the hypothesis that more effectual baroreflex would be related to more effective Granger causal influence of SBP on HBI. Six obstructive sleep apnea (OSA) patients (apnea-hypopnea index, AHI ≥ 5 events/hr) and six normal subjects participated in the study. Their SBP and HBI during nocturnal sleep were obtained from a non-invasive continuous BP measurement device. While the BRE (mean ± SD) of normal subjects was 47.0 ± 4.0%, OSA patients exhibited the BRE of 34.0 ± 3.8%. The impaired baroreflex function of OSA patients can be explained by the physiological mechanism associated with recurrent hypoxic episodes during sleep. Thus, the significantly lower BRE in OSA patients verified the availability of Granger causality analysis to evaluate baroreflex during sleep. Furthermore, the range of BRE obtained from normal subjects was not overlapped with that obtained from OSA patients. It suggests the potential of BRE as a new helpful tool for diagnosing OSA.
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KEYWORD
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Baroreflex, Obstructive sleep apnea, Granger causality
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